Transcriptional Control of the pref-1 Gene in 3T3-L1 Adipocyte Differentiation

doi:10.1074/jbc.273.48.31751

Article

Transcriptional Control of the pref-1 Gene in 3T3-L1 Adipocyte Differentiation

1 Nov 1998

Abstract excerpt

Preadipocyte factor-1 (Pref-1) is a transmembrane epidermal growth factor-like domain-containing protein highly expressed in 3T3-L1 preadipocytes, but is undetectable in mature fat cells; this down-regulation is required for adipocyte differentiation. We show here that pref-1 transcription is markedly suppressed during adipose conversion and results in decreased Pref-1 RNA levels. Using 3T3-L1 cells stably...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.