Article
Genetic contribution of the tumor necrosis factor region in Guillain-Barré syndrome.
Annals of neurology - 1 Nov 1998
Ma J J, Nishimura M, Mine H, Kuroki S, Nukina M, Ohta M, Saji H, Obayashi H, Kawakami H, Saida T, Uchiyama T
Abstract excerpt
We studied genetic polymorphisms in the tumor necrosis factor (TNF) region in 81 Japanese patients with Guillain-Barré syndrome (GBS) and 85 controls. A significantly higher frequency of the 100-base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNF alpha production, existed in Campylobacter jejuni-positive (Cj+) GBS patients than in controls, suggesting the involvement...
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