Article
Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors.
Chemistry & biology - 1 Oct 1998
Rodgers J D, Lam P Y, Johnson B L, Wang H, Li R, Ru Y, Ko S S, Seitz S P, Trainor G L, Anderson P S, Klabe R M, Bacheler L T, Cordova B, Garber S, Reid C, Wright M R, Chang C H, Erickson-Viitanen S
Abstract excerpt
BACKGROUND: Recent clinical trials have demonstrated that HIV protease inhibitors are useful in the treatment of AIDS. It is necessary, however, to use HIV protease inhibitors in combination with other antiviral agents to inhibit the development of resistance. The daunting ability of the virus to...
Topics
- Animals
- Anti-HIV Agents
- Crystallography, X-Ray
- Dogs
- Drug Design
- HIV
- HIV Protease Inhibitors
- Molecular Structure
- Mutation
- Protein Binding
- Urea
- Virus Replication