Article
bcl-2/bax expression and p53 gene status in human bladder cancer: relationship to early recurrence with intravesical chemotherapy after resection.
The Journal of urology - 1 Dec 1998
Ye D, Li H, Qian S, Sun Y, Zheng J, Ma Y
Abstract excerpt
PURPOSE: Studies have shown that the effects of chemotherapy depend on some biochemical mechanisms to induce apoptosis. Many genes are involved in apoptosis modulation, including p53, bcl-2 and bax. We determined the roles of p53 status and the ratio of bcl-2/bax proteins for predicting the recur...
Topics
- Carcinoma, Transitional Cell
- Gene Expression Regulation, Neoplastic
- Genes, bcl-2
- Genes, p53
- History, 17th Century
- Humans
- Mutation
- Neoplasm Recurrence, Local
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Urinary Bladder Neoplasms
- bcl-2-Associated X Protein