Article
Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome.
Journal of the neurological sciences - 18 Sept 1998
Kawanishi C, Shimoda Y, Fujimaki J, Onishi H, Suzuki K, Hanihara T, Sugiyama N, Kosaka K
Abstract excerpt
Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring...
Topics
- Alleles
- Amino Acid Substitution
- Antipsychotic Agents
- Cytochrome P-450 CYP2D6
- DNA Mutational Analysis
- Genetic Predisposition to Disease
- Homozygote
- Humans
- Inactivation, Metabolic
- Male
- Microsomes, Liver
- Middle Aged
- Neuroleptic Malignant Syndrome
- Point Mutation