Article
Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus.
Molecular and biochemical parasitology - 15 Sept 1998
Blackhall W J, Liu H Y, Xu M, Prichard R K, Beech R N
Abstract excerpt
Resistance to anthelmintics that are used to control parasite populations in domestic animals has become a serious problem worldwide. The development of resistance is an evolutionary process that leads to genetic changes in parasite populations in response to drug exposure. The anthelmintic iverm...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Alleles
- Animals
- Anti-Bacterial Agents
- Antinematodal Agents
- DNA, Helminth
- Drug Resistance
- Gene Frequency
- Genes, Helminth
- Genetic Variation
- Haemonchus
- Humans
- Ivermectin
- Macrolides
- Mice
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Selection, Genetic