Article
Familial hypertrophic cardiomyopathy: a paradigm of the cardiac hypertrophic response to injury.
Annals of medicine - 1 Aug 1998
Marian A J, Roberts R
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease caused by mutations in sarcomeric proteins. It is characterized by left ventricular hypertrophy in the absence of an increased external load, and myofibrillar disarray. While hypertrophy is a common cardiac response to injury, dis...
Topics
- Animals
- Cardiomyopathy, Hypertrophic
- Heart Injuries
- Humans
- Hypertrophy, Left Ventricular
- Mice
- Mutation
- Pedigree
- Prognosis
- Sarcomeres