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Technical Report A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry

1 Jan 1998

Abstract excerpt

PURPOSE: To find a simple protocol for measuring chromosome damage both in G1 and in G2/M chromosomes, to overcome problems related to low mitotic index and cell-cycle alterations in biodosimetric tests. MATERIALS AND METHODS: The protocol is based on the use of calyculin A to induce premature chromosome condensation in human peripheral blood lymphocytes in different phases of the cell cycle. Chromosome exchanges...

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PMID: 9798956
DOI: 10.1080/095530098141320

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