Purification and Characterization of Virginiamycin M 1 Reductase from Streptomyces virginiae

doi:10.1128/aac.42.11.2985

Article

Purification and Characterization of Virginiamycin M 1 Reductase from Streptomyces virginiae

1 Nov 1998

Abstract excerpt

Virginiamycin M1 (VM1), produced by Streptomyces virginiae, is a polyunsaturated macrocyclic lactone antibiotic belonging to the virginiamycin A group. S. virginiae possesses an activity which stereospecifically reduces a 16-carbonyl group of VM1, resulting in antibiotically inactive 16R-dihydroVM1. The corresponding VM1 reductase was purified to homogeneity from crude extracts of S. virginiae in five steps, with...

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