Article
Autosomal dominant nanophthalmos (NNO1) with high hyperopia and angle-closure glaucoma maps to chromosome 11.
American journal of human genetics - 1 Nov 1998
Othman M I, Sullivan S A, Skuta G L, Cockrell D A, Stringham H M, Downs C A, Fornés A, Mick A, Boehnke M, Vollrath D, Richards J E
Abstract excerpt
Nanophthalmos is an uncommon developmental ocular disorder characterized by a small eye, as indicated by short axial length, high hyperopia (severe farsightedness), high lens/eye volume ratio, and a high incidence of angle-closure glaucoma. We performed clinical and genetic evaluations of members...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Eye Abnormalities
- Female
- Genes, Dominant
- Genetic Markers
- Genotype
- Glaucoma, Angle-Closure
- Humans
- Hyperopia
- Lod Score
- Male
- Pedigree
- Spouses