Article
Low T-cell responses to CD3 plus CD28 monoclonal antibodies are predictive of development of AIDS.
AIDS (London, England) - 1 Oct 1998
Roos M T, Prins M, Koot M, de Wolf F, Bakker M, Coutinho R A, Miedema F, Schellekens P T
Abstract excerpt
OBJECTIVE: Decreased T-cell reactivity in vitro is strongly associated with progression to AIDS and low CD4+ T-cell numbers. Low T-cell responses in vitro induced by CD3 monoclonal antibody (mAb) are predictive for progression to AIDS independent of low CD4+ T-cell counts and high HIV-1 RNA levels. We developed a whole-blood lymphocyte culture system in which T cells were stimulated by a combination of CD3 and...
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