Article
Low T-cell responses to CD3 plus CD28 monoclonal antibodies are predictive of development of AIDS.
AIDS (London, England) - 1 Oct 1998
Roos M T, Prins M, Koot M, de Wolf F, Bakker M, Coutinho R A, Miedema F, Schellekens P T
Abstract excerpt
OBJECTIVE: Decreased T-cell reactivity in vitro is strongly associated with progression to AIDS and low CD4+ T-cell numbers. Low T-cell responses in vitro induced by CD3 monoclonal antibody (mAb) are predictive for progression to AIDS independent of low CD4+ T-cell counts and high HIV-1 RNA level...
Topics
- Antibodies, Monoclonal
- CD28 Antigens
- CD3 Complex
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Cohort Studies
- Disease Progression
- HIV Infections
- HIV-1
- Homosexuality, Male
- Humans
- Longitudinal Studies
- Lymphocyte Activation
- Male
- Multivariate Analysis
- Phenotype
- Predictive Value of Tests
- Prospective Studies