Article
Pathobiologic characteristics of hereditary breast cancer.
Human pathology - 1 Oct 1998
Lynch B J, Holden J A, Buys S S, Neuhausen S L, Gaffney D K
Abstract excerpt
Patients with hereditary breast cancer (HBC) present at a young age with breast cancers that show adverse pathological characteristics such as high nuclear grade, negative hormone receptor status, and high proliferation indices. Surprisingly, the clinical course has been reported to be comparable...
Topics
- Adult
- Aged
- BRCA1 Protein
- BRCA2 Protein
- Biomarkers, Tumor
- Breast Neoplasms
- Female
- Humans
- Middle Aged
- Mitosis
- Mutation
- Neoplasm Proteins
- Neoplastic Syndromes, Hereditary
- Receptor, ErbB-2
- Transcription Factors
- Tumor Suppressor Protein p53