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Article

The Semliki Forest virus vector induces p53-independent apoptosis.

1 Oct 1998

Abstract excerpt

Three deletion mutants of the structural protein region of the Semliki Forest virus (SFV) genome, including one which encompassed all the viral structural protein genes, induced apoptosis in BHK cells at 48 h after transfection, as shown by DNA laddering and TUNEL staining, as did the wild-type SFV4 RNA. A similar result was obtained for the SFV1 expression vector, which has a multicloning site inserted in place...

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PMID: 9780045
DOI: 10.1099/0022-1317-79-10-2405

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