Article
Peptide containing the BCR oligomerization domain (AA 1-160) reverses the transformed phenotype of p210bcr-abl positive 32D myeloid leukemia cells.
Oncogene - 20 Aug 1998
Guo X Y, Cuillerot J M, Wang T, Wu Y, Arlinghaus R, Claxton D, Bachier C, Greenberger J, Colombowala I, Deisseroth A B
Abstract excerpt
We first showed that the introduction of a bcr-abl transcription unit into the 32D murine myeloid cell line (P210bcrabl32D) converts this cell line from an IL3 dependent cell line to an IL3 growth independent cell line. We next cloned a fragment of the bcr-abl cDNA, which codes for the bcr oligom...
Topics
- Animals
- Cell Division
- Cell Line, Transformed
- Enhancer Elements, Genetic
- Fusion Proteins, bcr-abl
- Genes, abl
- Humans
- Interleukin-3
- K562 Cells
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Mice
- Phenotype
- Plasmids
- Protein-Tyrosine Kinases