Article
A misfolded protein conformation is not a sufficient condition for in vivo glucosylation by the UDP-Glc:glycoprotein glucosyltransferase.
The EMBO journal - 15 Oct 1998
Fernández F, D'Alessio C, Fanchiotti S, Parodi A J
Abstract excerpt
A key element in the quality control of glycoprotein folding is the UDP-Glc:glycoprotein glucosyltransferase (GT), which in cell-free assays exclusively glucosylates misfolded glycoproteins. In order to test if such a protein conformation is a sufficient condition for in vivo glucosylation of all...
Topics
- Dithiothreitol
- Endoplasmic Reticulum
- Glucose
- Glucosyltransferases
- Heat-Shock Response
- Mutation
- Oligosaccharides
- Protein Conformation
- Protein Folding
- Protein Processing, Post-Translational
- Schizosaccharomyces