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Article

Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 1998

Levite M

Abstract excerpt

Searching for nervous system candidates that could directly induce T cell cytokine secretion, I tested four neuropeptides (NPs): somatostatin, calcitonin gene-related peptide, neuropeptide Y, and substance P. Comparing neuropeptide-driven versus classical antigen-driven cytokine secretion from T helper cells Th0, Th1, and Th2 autoimmune-related T cell populations, I show that the tested NPs, in the absence of any...

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Identifiers

PMID: 9770522
DOI: 10.1073/pnas.95.21.12544
PMCID: PMC22867

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