Article
[A three-dimensional model for in vitro study of the association of three antibiotics. Application to the activity of piperacillin, tazobactam and amikacin against five strains of enterobacteria as a function of their phenotype of beta-lactam resistance].
Pathologie-biologie - 1 Jan 1998
Duez J M, Cordin X, Siebor E, Pechinot A, Chamard-Neuwirth C, Kazmierczak A
Abstract excerpt
We described an in vitro 3-dimensional model to study the bactericidal activity of piperacillin (P), tazobactam (T) and amikacin (A) in combination against 5 strains of enterobacteria with different resistance patterns of beta-lactam antibiotics. A synergy was defined by calculation of sigma FBCP,T,A = BCp/MBCp + BCT/MBCT + BCA/MBCA and classic sigma FBCs for each double combination. The therapeutic value of each...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.