Article
[A three-dimensional model for in vitro study of the association of three antibiotics. Application to the activity of piperacillin, tazobactam and amikacin against five strains of enterobacteria as a function of their phenotype of beta-lactam resistance].
Pathologie-biologie - 1 Jan 1998
Duez J M, Cordin X, Siebor E, Pechinot A, Chamard-Neuwirth C, Kazmierczak A
Abstract excerpt
We described an in vitro 3-dimensional model to study the bactericidal activity of piperacillin (P), tazobactam (T) and amikacin (A) in combination against 5 strains of enterobacteria with different resistance patterns of beta-lactam antibiotics. A synergy was defined by calculation of sigma FBCP...
Topics
- Amikacin
- Anti-Bacterial Agents
- Drug Therapy, Combination
- Enterobacteriaceae
- Enzyme Inhibitors
- Microbial Sensitivity Tests
- Models, Biological
- Penicillanic Acid
- Penicillins
- Phenotype
- Piperacillin
- Tazobactam
- beta-Lactam Resistance
- beta-Lactamase Inhibitors