Article
Chimeras and mosaics in mouse mutant analysis.
Trends in genetics : TIG - 1 Sept 1998
Rossant J, Spence A
Abstract excerpt
As the number of mouse mutants generated by gene targeting continues to grow exponentially, the challenge is not how to generate a mutant but how to analyse the phenotype. Genes might play multiple roles in development and act in cell-autonomous and cell non-autonomous modes, making phenotypic analysis complex. Genetic mosaic analysis is a powerful tool for dissecting complex gene functions. Classical...
Topics
- Animals
- Chimera
- Gene Targeting
- Mice
- Mice, Mutant Strains
- Mosaicism
- Mutation
- Phenotype