Article
Subsensitivity to bronchoprotection against adenosine monophosphate challenge following regular once-daily formoterol.
The European respiratory journal - 1 Sept 1998
Aziz I, Tan K S, Hall I P, Devlin M M, Lipworth B J
Abstract excerpt
Regular treatment with inhaled long-acting beta2-agonists leads to subsensitivity to their bronchoprotective effects, although the effect of dosing frequency on this subsensitivity is not known. The aim of this study was to assess whether a once-daily dosing regimen with formoterol might be assoc...
Topics
- Adenosine Monophosphate
- Administration, Oral
- Adrenergic beta-Agonists
- Adult
- Asthma
- Bronchi
- Bronchial Hyperreactivity
- Bronchial Provocation Tests
- Confidence Intervals
- Cross-Over Studies
- Double-Blind Method
- Drug Administration Schedule
- Drug Tolerance
- Ethanolamines
- Female
- Forced Expiratory Volume
- Formoterol Fumarate
- Genotype