Article
Atypical protein kinase Clambda binds and regulates p70 S6 kinase.
The Biochemical journal - 15 Oct 1998
Akimoto K, Nakaya M, Yamanaka T, Tanaka J, Matsuda S, Weng Q P, Avruch J, Ohno S
Abstract excerpt
p70 S6 kinase (p70 S6K) has been implicated in the regulation of cell cycle progression. However, the mechanism of its activation is not fully understood. In the present work, evidence is provided that an atypical protein kinase C (PKC) isotype, PKClambda, is indispensable, but not sufficient, fo...
Topics
- Amino Acid Sequence
- Animals
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- DNA-Binding Proteins
- E2F Transcription Factors
- Enzyme Activation
- Gene Expression Regulation
- Humans
- Isoenzymes
- Molecular Sequence Data
- Mutation
- Platelet-Derived Growth Factor
- Protein Kinase C