Article
Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians.
Clinical chemistry - 1 Oct 1998
Faure-Delanef L, Baudin B, Bénéteau-Burnat B, Beaudoin J C, Giboudeau J, Cohen D
Abstract excerpt
We have determined serum activity and kinetic constants of angiotensin I-converting enzyme (ACE), parallel to an insertion/deletion (I/D) polymorphism in its gene, in French centenarians and controls 20-70 years of age because this enzyme could have an impact on cardiovascular risk, and thus on longevity. Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls,...
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