Article
Shift from Rh-positive to Rh-negative phenotype caused by a somatic mutation within the RHD gene in a patient with chronic myelocytic leukaemia.
British journal of haematology - 1 Sept 1998
Chérif-Zahar B, Bony V, Steffensen R, Gane P, Raynal V, Goosens D, Laursen J S, Varming K, Jersild C, Cartron J P
Abstract excerpt
We report a female patient whose Rh phenotype shifted from RhD-positive to RhD-negative over a 3-year period (1991-94), during which time she was treated with mastectomy (1992) and local irradiation for a low-grade recurrent breast cancer. She was diagnosed with chronic myeloid leukaemia in 1994,...
Topics
- Aged
- Amino Acid Sequence
- Base Sequence
- Blotting, Southern
- Erythroblasts
- Female
- Gene Deletion
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Lymphocytes
- Molecular Sequence Data
- Mutation
- Reverse Transcriptase Polymerase Chain Reaction