Abnormal regulation of the leptin gene in the pathogenesis of obesity.

doi:10.1073/pnas.95.20.11852

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Article

Abnormal regulation of the leptin gene in the pathogenesis of obesity.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Ioffe E, Moon B, Connolly E, Friedman J M

Abstract excerpt

A subset of obese humans has relatively low plasma levels of leptin. This finding has suggested that in some cases abnormal regulation of the leptin gene in adipose tissue is etiologic in the pathogenesis of the obese state. The possibility that a relative decrease in leptin production can lead t...

Topics

Adipocytes
Animals
Base Sequence
Cell Count
DNA Primers
Eating
Female
Gene Expression Regulation
Humans
Leptin
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Mice, Transgenic
Obesity
Phenotype
Polymerase Chain Reaction

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