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Article

Abnormal regulation of the leptin gene in the pathogenesis of obesity.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Ioffe E, Moon B, Connolly E, Friedman J M

Abstract excerpt

A subset of obese humans has relatively low plasma levels of leptin. This finding has suggested that in some cases abnormal regulation of the leptin gene in adipose tissue is etiologic in the pathogenesis of the obese state. The possibility that a relative decrease in leptin production can lead to obesity was tested by mating animals carrying a weakly expressed adipocyte specific aP2-human leptin transgene to...

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Identifiers

PMID: 9751754
DOI: 10.1073/pnas.95.20.11852
PMCID: PMC21729

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