Article
The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion.
The Journal of biological chemistry - 2 Oct 1998
Yang Y, Turner R S, Gaut J R
Abstract excerpt
Recent studies of cellular amyloid precursor protein (APP) metabolism demonstrate a beta-/gamma-secretase pathway resident to the endoplasmic reticulum (ER)/Golgi resulting in intracellular generation of soluble APP (APPsbeta) and Abeta42 peptide. Thus, these intracellular compartments may be key...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Carrier Proteins
- Cell Line
- Culture Media, Conditioned
- Endoplasmic Reticulum
- Endoplasmic Reticulum Chaperone BiP
- Heat-Shock Proteins
- Humans
- Molecular Chaperones
- Mutation
- Peptide Fragments
- Precipitin Tests
- Protein Binding
- Protein Folding
- Protein Processing, Post-Translational
- Transfection