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Article

Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function.

Genes & development - 15 Sept 1998

Milán M, Diaz-Benjumea F J, Cohen S M

Abstract excerpt

Formation of the dorsal-ventral axis of the Drosophila wing depends on activity of the LIM-homeodomain protein Apterous (Ap). Here we report that Ap activity levels are modulated by dLMO, the protein encoded by the Beadex (Bx) gene. Overexpression of dLMO in Bx mutants interferes with Apterous function. Conversely, Bx loss-of-function mutants fail to down-regulate Apterous activity at late stages of wing...

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Identifiers

PMID: 9744867
DOI: 10.1101/gad.12.18.2912
PMCID: PMC317163

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Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function.PMID 9744867Read ↗

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