Article
Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function.
Genes & development - 15 Sept 1998
Milán M, Diaz-Benjumea F J, Cohen S M
Abstract excerpt
Formation of the dorsal-ventral axis of the Drosophila wing depends on activity of the LIM-homeodomain protein Apterous (Ap). Here we report that Ap activity levels are modulated by dLMO, the protein encoded by the Beadex (Bx) gene. Overexpression of dLMO in Bx mutants interferes with Apterous fu...
Topics
- Animals
- Base Sequence
- DNA Primers
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Genes, Insect
- Homeodomain Proteins
- In Situ Hybridization
- Insect Proteins
- LIM-Homeodomain Proteins
- Macromolecular Substances
- Models, Biological
- Molecular Sequence Data
- Mutagenesis, Insertional
- Nuclear Proteins
- Oncogenes