Article
Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998
Salehi A, Dubelaar E J, Mulder M, Swaab D F
Abstract excerpt
As reported before, the metabolic activity of nucleus basalis neurons is reduced significantly in Alzheimer patients. Because the apolipoprotein E (ApoE) epsilon4 genotype is a major risk factor for Alzheimer's disease (AD), we determined whether the decrease in metabolic activity in nucleus basa...
Topics
- Adult
- Aged
- Alleles
- Alzheimer Disease
- Antibodies
- Apolipoproteins E
- Genotype
- Golgi Apparatus
- Humans
- Immunohistochemistry
- Middle Aged
- Neurons
- Receptors, Cell Surface
- Receptors, Fibroblast Growth Factor
- Risk Factors
- Sialoglycoproteins
- Substantia Innominata