Cbfa1 in bone development.

doi:10.1016/s0959-437x(98)80123-8

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Article

Cbfa1 in bone development.

Current opinion in genetics & development - 1 Aug 1998

Komori T, Kishimoto T

Abstract excerpt

A factor fundamental to bone formation has been identified. Gene targeting shows that core-binding factor alpha 1 (Cbfa1) plays an essential role in bone formation and osteoblast differentiation. Thus, it is now possible to begin examining the molecular mechanism of bone formation--especially ost...

Topics

Animals
Bone Development
Cell Differentiation
Cleidocranial Dysplasia
Core Binding Factor Alpha 1 Subunit
Core Binding Factors
Gene Expression
Humans
Mice
Mutation
Neoplasm Proteins
Osteoblasts
Transcription Factors

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