Article
Apolipoprotein(a) binds via its C-terminal domain to the protein core of the proteoglycan decorin. Implications for the retention of lipoprotein(a) in atherosclerotic lesions.
The Journal of biological chemistry - 11 Sept 1998
Klezovitch O, Edelstein C, Zhu L, Scanu A M
Abstract excerpt
Although it is known that lipoprotein(a) (Lp(a)) binds to proteoglycans, the mechanism for this binding has not been fully elucidated. In order to shed light on this subject, we examined the interactions of decorin, a proteoglycan with a well defined protein core and a single glycosaminoglycan (G...
Topics
- Animals
- Apolipoproteins
- Apoprotein(a)
- Binding Sites
- Cartilage, Articular
- Cattle
- Circular Dichroism
- Decorin
- Extracellular Matrix Proteins
- Genotype
- Guanidine
- Humans
- Kinetics
- Lipoprotein(a)
- Pancreatic Elastase
- Peptide Fragments
- Phenotype
- Protein Conformation