Article
Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5.
The Journal of biological chemistry - 4 Sept 1998
Okajima Y, Matsumura I, Nishiura T, Hashimoto K, Yoshida H, Ishikawa J, Wakao H, Yoshimura A, Kanakura Y, Tomiyama Y, Matsuzawa Y
Abstract excerpt
Insulin-like growth factor (IGF-I) is known to synergistically stimulate the proliferation of hematopoietic cells in combination with other hematopoietic growth factors. However, the precise mechanism underlying the cooperative effects of IGF-I is unknown. In a human interleukin-3 or erythropoiet...
Topics
- Cell Division
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Drug Synergism
- Erythropoietin
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Insulin-Like Growth Factor I
- Interleukin-3
- Janus Kinase 2
- Leukemia, Erythroblastic, Acute
- Milk Proteins
- Mutation