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Article

Evolution by nearly-neutral mutations.

Genetica - 1 Jan 1998

Ohta T

Abstract excerpt

Genetic systems are complex and interact at various levels; among amino acids or nucleotide sites, among gene products, and among regulatory regions and proteins. Patterns of synonymous and nonsynonymous substitutions of mammalian genes indicate that nonsynonymous substitutions are nearly neutral, coming from interactions among amino acids. As an interactive system, the NK model of Kauffman was analysed. This...

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PMID: 9720273

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