Article
Mitochondrial dysfunction in neurodegenerative disorders.
Biochimica et biophysica acta - 10 Aug 1998
Schapira A H
Abstract excerpt
Mutations of mitochondrial DNA (mtDNA) are associated with a wide spectrum of disorders encompassing the myopathies, encephalopathies and cardiomyopathies, in addition to organ specific presentations such as diabetes mellitus and deafness. The pathogenesis of mtDNA mutations is not fully understo...
Topics
- Animals
- DNA, Mitochondrial
- Energy Metabolism
- Friedreich Ataxia
- Humans
- Huntington Disease
- Iron-Binding Proteins
- Mitochondria
- Mutation
- NAD(P)H Dehydrogenase (Quinone)
- Neurodegenerative Diseases
- Oxidative Phosphorylation