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Article

Genomic origin and transcriptional regulation of two variants of cGMP‐binding cGMP‐specific phosphodiesterases

1 Jun 1999

Abstract excerpt

We have reported alternative splice variants of cGMP-binding cGMP-specific phosphodiesterases (PDE5A), i.e. rat PDE5A2, human PDE5A1, canine PDE5A1 and PDE5A2, which possess distinct N-terminal sequences. In this study, the DNA sequences corresponding to the unique N-terminal portions of PDE5A1 and PDE5A2 were shown to be tandemly located upstream of exons encoding the common region of PDE5A in both human and rat...

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PMID: 10411650
DOI: 10.1046/j.1432-1327.1999.00450.x

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