A gene essential to brain growth and development maps to the distal arm of rat chromosome 12.

doi:10.1016/s0304-3940(98)00478-9

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Article

A gene essential to brain growth and development maps to the distal arm of rat chromosome 12.

Neuroscience letters - 17 Jul 1998

Cogswell C A, Sarkisian M R, Leung V, Patel R, D'Mello S R, LoTurco J J

Abstract excerpt

A recently discovered, spontaneous, autosomal recessive mutation in rats, flathead (fh), results in greatly reduced brain growth beginning in late fetal development. In this study we have mapped the fh mutation by determining the pattern of segregation of polymorphic microsatellite markers with r...

Topics

Aging
Animals
Brain
Chromosome Mapping
Crosses, Genetic
Embryonic and Fetal Development
Female
Genes, Essential
Genes, Recessive
Genetic Markers
Homozygote
Humans
Lod Score
Male
Mice
Phenotype
Rats
Rats, Mutant Strains

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