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Article

Mutation in NS5 protein attenuates mouse neurovirulence of yellow fever 17D vaccine virus.

The Journal of general virology - 1 Aug 1998

Xie H, Ryman K D, Campbell G A, Barrett A D

Abstract excerpt

The 17D-204 vaccine manufactured in South Africa (17D-204-SA) and a large plaque variant (17D-LP) derived from it were highly virulent in adult mice. The LD50 of 17D-LP virus was 0-2 p.f.u. for mice following intracerebral inoculation. In comparison, a medium plaque variant derived from 17D-LP, termed 17D-MP virus, was found to be attenuated in adult mice following the same route of inoculation (> 10(4)...

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Identifiers

PMID: 9714237
DOI: 10.1099/0022-1317-79-8-1895

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