Mutation in NS5 protein attenuates mouse neurovirulence of yellow fever 17D vaccine virus.

doi:10.1099/0022-1317-79-8-1895

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Article

Mutation in NS5 protein attenuates mouse neurovirulence of yellow fever 17D vaccine virus.

The Journal of general virology - 1 Aug 1998

Xie H, Ryman K D, Campbell G A, Barrett A D

Abstract excerpt

The 17D-204 vaccine manufactured in South Africa (17D-204-SA) and a large plaque variant (17D-LP) derived from it were highly virulent in adult mice. The LD50 of 17D-LP virus was 0-2 p.f.u. for mice following intracerebral inoculation. In comparison, a medium plaque variant derived from 17D-LP, t...

Topics

Amino Acid Sequence
Animals
Base Sequence
Brain
Cell Line
Chlorocebus aethiops
DNA, Viral
Female
Macaca mulatta
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation
Vaccines, Attenuated
Vero Cells
Viral Nonstructural Proteins
Viral Plaque Assay
Viral Vaccines

Source

Open in PubMed

Identifiers

PMID: 9714237
DOI: 10.1099/0022-1317-79-8-1895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9714237-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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