Article
Frequency of MAGE-3 gene expression in HLA-A2 positive patients with non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 May 1998
Gotoh K, Yatabe Y, Sugiura T, Takagi K, Ogawa M, Takahashi T, Takahashi T, Mitsudomi T
Abstract excerpt
Melanoma tumor antigens, MAGE-1 and -3 are presented on HLA-A1 and -Cw*1601, or -A1 and -A2, respectively, to the corresponding cytotoxic T lymphocytes (CTL). If CTL recognizing these antigens were generated in patients, clones of positive tumor cells should be eliminated. To ascertain whether su...
Topics
- Adult
- Aged
- Antibodies, Monoclonal
- Antigens, Neoplasm
- Carcinoma, Non-Small-Cell Lung
- Chi-Square Distribution
- DNA Primers
- Female
- Gene Amplification
- Gene Expression
- Genotype
- HLA Antigens
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Multigene Family
- Neoplasm Staging