Article
APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells.
The EMBO journal - 17 Aug 1998
Rassoulzadegan M, Yang Y, Cuzin F
Abstract excerpt
The mouse amyloid precursor-like protein 2 (APLP2) belongs to the Alzheimer peptide precursor family. A possible role in pre-implantation development had been suggested previously, and was investigated further by creating a large deletion in the genomic locus. While heterozygous mice developed no...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Apoptosis
- Base Sequence
- Cells, Cultured
- DNA Primers
- DNA Replication
- Embryo, Mammalian
- Embryonic and Fetal Development
- Genomic Imprinting
- Heterozygote
- Homozygote
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutation
- Nerve Tissue Proteins