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Article

APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells.

The EMBO journal - 17 Aug 1998

Rassoulzadegan M, Yang Y, Cuzin F

Abstract excerpt

The mouse amyloid precursor-like protein 2 (APLP2) belongs to the Alzheimer peptide precursor family. A possible role in pre-implantation development had been suggested previously, and was investigated further by creating a large deletion in the genomic locus. While heterozygous mice developed normally, homozygous embryos were arrested before reaching the blastocyst stage. One-cell embryos which contained protein...

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Source

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Identifiers

PMID: 9707424
DOI: 10.1093/emboj/17.16.4647
PMCID: PMC1170794

Genes

APLP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells.PMID 9707424Read ↗

Transcription factor gene AP-2 gamma essential for early murine development.Semantic proximity Read ↗

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Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.Semantic proximity Read ↗

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth.Semantic proximity Read ↗

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.Semantic proximity Read ↗

ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.Semantic proximity Read ↗

Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants.Semantic proximity Read ↗

Conserved alternative and antisense transcripts at the programmed cell death 2 locus.Semantic proximity Read ↗

Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or functionSemantic proximity Read ↗

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