Cyclosporin A and hydroxycyclosporine (M-17) affect the secretory phenotype of human gingival fibroblasts.

doi:10.1111/j.1600-0714.1998.tb01953.x

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Article

Cyclosporin A and hydroxycyclosporine (M-17) affect the secretory phenotype of human gingival fibroblasts.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jul 1998

Mariotti A, Hassell T, Jacobs D, Manning C J, Hefti A F

Abstract excerpt

The responsiveness of human gingival fibroblast populations to cyclosporin A (CsA) and its principal metabolite, hydroxycyclosporine (M17), was evaluated in cell culture. Gingival fibroblasts exhibited a dose-dependent accumulation and bell-shaped distribution of dansylated CsA. A 100-fold excess...

Topics

Adolescent
Adult
Aged
Analysis of Variance
Cell Count
Cell Division
Cell Separation
Cells, Cultured
Collagen
Cyclosporine
Cyclosporins
Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Fibroblasts

Flow Cytometry

Fluorescent Dyes

Gingiva

Humans

Source

Open in PubMed

Identifiers

PMID: 9707278
DOI: 10.1111/j.1600-0714.1998.tb01953.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9707278-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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