Article
Association of an X-chromosome dodecamer insertional variant allele with mental retardation.
Molecular psychiatry - 1 Jul 1998
Philibert R A, King B H, Winfield S, Cook E H, Lee Y H, Stubblefield B, Damschroder-Williams P, Dea C, Palotie A, Tengstrom C, Martin B M, Ginns E I
Abstract excerpt
Mental retardation is a prominent feature of many neurodevelopmental syndromes. In an attempt to identify genetic components of these illnesses, we isolated and sequenced a large number of human genomic cosmid inserts containing large trinucleotide repeats. One of these cosmids, Cos-4, maps to the X-chromosome and contains the sequence of a 7.3-kb mRNA. Initial polymorphism analysis across a region of repetitive...
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