Article
A unique form of proliferating cell nuclear antigen is present in malignant breast cells.
Cancer research - 1 Aug 1998
Bechtel P E, Hickey R J, Schnaper L, Sekowski J W, Long B J, Freund R, Liu N, Rodriguez-Valenzuela C, Malkas L H
Abstract excerpt
Despite extensive research efforts to identify unique molecular alterations in breast cancer, to date, no characteristic has emerged that correlates exclusively with malignancy. Recently, it has been shown that the multiprotein DNA replication complex (synthesome) from breast cancer cells has a significantly decreased replication fidelity compared to that of nonmalignant breast cells. Proliferating cell nuclear...
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