Article
Chemosensitivity of lymphocytes from patients with B-cell chronic lymphocytic leukemia to chlorambucil, fludarabine, and camptothecin analogs.
Blood - 15 Nov 1994
Silber R, Degar B, Costin D, Newcomb E W, Mani M, Rosenberg C R, Morse L, Drygas J C, Canellakis Z N, Potmesil M
Abstract excerpt
Chemosensitivity of B lymphocytes, obtained from 65 patients with B-cell chronic lymphocytic leukemia (B-CLL), Rai stages 0 through IV, was determined using the MTT assay. The results were expressed by the drug concentration required for 50% inhibition of cell viability (IC50). The cytotoxicity o...
Topics
- Antineoplastic Agents
- B-Lymphocytes
- Camptothecin
- Cell Survival
- Cells, Cultured
- Chlorambucil
- Genes, p53
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Mutation
- Neoplasm Staging
- Sensitivity and Specificity
- Tumor Cells, Cultured
- Vidarabine