Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Indole-3-Carbinol Synergizes with and Restores Fludarabine Sensitivity in Chronic Lymphocytic Leukemia Cells Irrespective of p53 Activity and Treatment Resistances.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2016

Perez-Chacon Gema, Martinez-Laperche Carolina, Rebolleda Nerea, Somovilla-Crespo Beatriz, Muñoz-Calleja Cecilia, Buño Ismael, Zapata Juan M

Abstract excerpt

PURPOSE: Chronic lymphocytic leukemia (CLL) still is lacking a cure. Relapse and development of refractoriness to current treatments are common. New therapies are needed to improve patient prognosis and survival. EXPERIMENTAL DESIGN: Indole-3-carbinol (I3C) is a natural product with antitumor pro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 9
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Synergism

Share to Immunoglobulin Heavy Chains

Share to Indoles

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Vidarabine

Share to X-Linked Inhibitor of Apoptosis Protein

Source

Identifiers

PMID: 26324744
DOI: 10.1158/1078-0432.CCR-15-0736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26324744-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Indole-3-Carbinol Synergizes with and Restores Fludarabine Sensitivity in Chronic Lymphocytic Leukemia Cells Irrespective of p53 Activity and Treatment Resistances.PMID 26324744Read ↗

A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Fludarabine treatment of patients with chronic lymphocytic leukemia induces a p53-dependent gene expression responseSemantic proximity Read ↗

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.Semantic proximity Read ↗

Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agentsSemantic proximity Read ↗

Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia.Semantic proximity Read ↗

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia.Semantic proximity Read ↗

Studies of glucocorticord resistance in chronic lymphocytic leukaemiaSemantic proximity Read ↗

Indole‐3‐carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cellsSemantic proximity Read ↗

Ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab (iFCG) regimen for chronic lymphocytic leukemia (CLL) with mutated IGHV and without TP53 aberrations.Semantic proximity Read ↗

Antiviral Treatment of HCV-Infected Patients with B-Cell Non-Hodgkin Lymphoma: ANRS HC-13 Lympho-C Study.Semantic proximity Read ↗

In vitro chemosensitivity of chronic lymphocytic leukaemia to purine analogues--correlation with clinical course.Semantic proximity Read ↗

MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.