Article
Detection of hepatitis C virus RNA by in situ hybridization in paraformaldehyde fixed biopsies.
Memorias do Instituto Oswaldo Cruz - 1 May 2005
Carvalho H S, Baptista M L, Pinto M A, Silva M, Takiya C M, Chagas V, Pannain V, Coelho H S M, Yoshida C F T
Abstract excerpt
Fourteen hepatitis C virus (HCV) chronically infected patients were submitted to routine liver biopsy for histological evaluation. Liver samples were assayed to HCV-RNA by in situ hybridization, using digoxigenin labeled probe. HCV genotypes were found to be predominantly type 1 (71.4%), followed by genotype 3 (21.4%), and genotype 2 (7.2%). Alanine-aminotransferase levels were raised in 10 patients. The...
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