Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of ribozymes by deoxyribonucleotides and the origin of DNA.

Journal of molecular evolution - 1 Aug 1998

León P E

Abstract excerpt

Two catalytic functions were required, minimally, for the appearance of DNA in evolution: a ribonucleotide reductase (RNR) and a reverse transcriptase (RT). If one accepts the explanatory strength of the RNA world model, it is clear that DNA molecules arose in the RNA world at some stage during the early evolution of cells. I suggest that competition for limited and valuable resources such as nucleotides, amino...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyribonucleotides
Share to DNA
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Models, Theoretical

Share to Mutation

Share to RNA, Catalytic

Share to RNA-Directed DNA Polymerase

Source

Identifiers

PMID: 9694660
DOI: 10.1007/pl00006368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of ribozymes by deoxyribonucleotides and the origin of DNA.PMID 9694660Read ↗

The RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)(a).Semantic proximity Read ↗

Life should be redefined: Any molecule with the ability to self-replicate should be considered lifeSemantic proximity Read ↗

Getting a DNA to do an RNA's job.Semantic proximity Read ↗

Darwinian behavior in a cold, sporadically fed pool of ribonucleotides.Semantic proximity Read ↗

The Balancing Act of Ribonucleotides in DNA.Semantic proximity Read ↗

The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA.Semantic proximity Read ↗

Hypothesis on the significance of RNA-directed DNA synthesis for evolution.Semantic proximity Read ↗

The ancient history of the structure of ribonuclease P and the early origins of Archaea.Semantic proximity Read ↗

Ribozyme-catalyzed transcription of an active ribozyme.Semantic proximity Read ↗

An Unexplored Diversity of Reverse Transcriptases in Bacteria.Semantic proximity Read ↗

Drawbacks of the ancient RNA-based life-like system under primitive earth conditions.Semantic proximity Read ↗

A ribozyme that lacks cytidine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.