Chromosomal fragility may be indicative of altered higher-order DNA organization as the underlying genetic diathesis in complex neurobehavioral disorders.

doi:10.1016/s0306-9877(98)90004-4

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Article

Chromosomal fragility may be indicative of altered higher-order DNA organization as the underlying genetic diathesis in complex neurobehavioral disorders.

Medical hypotheses - 1 Apr 1998

Gericke G S

Abstract excerpt

Preliminary observations concerning increased chromosomal fragility in association with behavioural disorders in humans allow an opportunity to suggest a cohesive theory regarding the possible importance of higher-order DNA modifications in the coordination of gene function in brain evolution and...

Topics

Chromosome Breakage
DNA
DNA Transposable Elements
Genetic Predisposition to Disease
Humans
Models, Genetic
Neuropsychological Tests
Nucleic Acid Conformation
Transcription, Genetic

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