Article
Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli.
Antimicrobial agents and chemotherapy - 1 Aug 1998
Oethinger M, Podglajen I, Kern W V, Levy S B
Abstract excerpt
The contribution of regulatory genes to fluoroquinolone resistance was studied with clinical Escherichia coli strains bearing mutations in gyrA and parC and with different levels of fluoroquinolone resistance. Expression of marA and soxS was evaluated by Northern blot analysis of isolates that de...
Topics
- Anti-Infective Agents
- Bacterial Proteins
- DNA Topoisomerases, Type I
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Escherichia coli
- Escherichia coli Proteins
- Fluoroquinolones
- Genes, Bacterial
- Genes, Regulator
- Humans
- Mutation
- Trans-Activators
- Transcription Factors