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Article

Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Aug 1998

Oethinger M, Podglajen I, Kern W V, Levy S B

Abstract excerpt

The contribution of regulatory genes to fluoroquinolone resistance was studied with clinical Escherichia coli strains bearing mutations in gyrA and parC and with different levels of fluoroquinolone resistance. Expression of marA and soxS was evaluated by Northern blot analysis of isolates that demonstrated increased organic solvent tolerance, a phenotype that has been linked to overexpression of marA, soxS, and...

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Identifiers

PMID: 9687412
DOI: 10.1128/AAC.42.8.2089
PMCID: PMC105868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli.PMID 9687412Read ↗

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Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York CitySemantic proximity Read ↗

Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli.Semantic proximity Read ↗

Absence of mutations in marRAB or soxRS in acrB-overexpressing fluoroquinolone-resistant clinical and veterinary isolates of Escherichia coli.Semantic proximity Read ↗

The multiple antibiotic resistance (mar) locus and its significance.Semantic proximity Read ↗

Genetic Characterization of Highly Fluoroquinolone-Resistant Clinical <i>Escherichia coli</i> Strains from China: Role of <i>acrR</i> MutationsSemantic proximity Read ↗

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Quorum-sensing regulator sdiA and marA overexpression is involved in in vitro-selected multidrug resistance of Escherichia coli.Semantic proximity Read ↗

Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli.Semantic proximity Read ↗

Role of an acrR mutation in multidrug resistance of in vitro-selected fluoroquinolone-resistant mutants of Salmonella enterica serovar Typhimurium.Semantic proximity Read ↗

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