Article
Failure to replicate an association between a rare allele of a tyrosine hydroxylase gene microsatellite and schizophrenia.
European archives of psychiatry and clinical neuroscience - 1 Jan 1998
Jönsson E G, Geijer T, Gyllander A, Terenius L, Sedvall G C
Abstract excerpt
An association between schizophrenia and a rare perfect ten-repeat allele, K1p, of a tetranucleotide microsatellite polymorphism in the tyrosine hydroxylase gene has recently been reported. The rare allele was found only in schizophrenic patients. During treatment with antipsychotic drugs patient...
Topics
- Alleles
- Gene Expression Regulation, Enzymologic
- Gene Frequency
- Homovanillic Acid
- Humans
- Hydroxyindoleacetic Acid
- Methoxyhydroxyphenylglycol
- Microsatellite Repeats
- Polymorphism, Genetic
- Reference Values
- Reproducibility of Results
- Schizophrenia
- Tyrosine 3-Monooxygenase