Article
Microsatellite behavior with range constraints: parameter estimation and improved distances for use in phylogenetic reconstruction.
Theoretical population biology - 1 Jun 1998
Pollock D D, Bergman A, Feldman M W, Goldstein D B
Abstract excerpt
A symmetric stepwise mutation model with reflecting boundaries is employed to evaluate microsatellite evolution under range constraints. Methods of estimating range constraints and mutation rates under the assumptions of the model are developed. Least squares procedures are employed to improve mo...
Topics
- Bias
- Data Interpretation, Statistical
- Gene Frequency
- Genetic Variation
- Least-Squares Analysis
- Microsatellite Repeats
- Models, Genetic
- Mutation
- Numerical Analysis, Computer-Assisted
- Phylogeny
- Reproducibility of Results