Article
Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosides.
The Journal of biological chemistry - 31 Jul 1998
Kawai H, Sango K, Mullin K A, Proia R L
Abstract excerpt
The dramatic changes in the expression of GD3 and other b-series gangliosides during neuronal development and morphogenesis have led to a widely held belief that these gangliosides may be necessary for neuronal differentiation. To determine directly if GD3 and b-series gangliosides are required f...
Topics
- Animals
- Cell Differentiation
- Gangliosides
- Gene Expression Regulation
- Gene Targeting
- Glycosphingolipids
- Mice
- Microtubule-Associated Proteins
- Mutation
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurofilament Proteins
- Neurons
- Sialyltransferases
- Stem Cells