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Article

Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population.

European journal of pediatrics - 1 Jun 1998

Koch M C, Stegmann K, Ziegler A, Schröter B, Ermert A

Abstract excerpt

UNLABELLED: A number of recent studies have demonstrated that the occurrence and recurrence risk of neural tube defects (NTD) is reduced by folic acid supplementation before and during pregnancy. Epidemiological studies have shown low plasma folate and raised plasma homocysteine in women with spina bifida aperta (SB) children suggesting an abnormal folate metabolism. The 5,10-methylenetetrahydrofolate reductase...

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Identifiers

PMID: 9667406
DOI: 10.1007/s004310050860

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population.PMID 9667406Read ↗

Altered folate and vitamin B12 metabolism in families with spina bifida offspringSemantic proximity Read ↗

The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy.Semantic proximity Read ↗

5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review.Semantic proximity Read ↗

Evaluation of infant methylenetetrahydrofolate reductase genotype, maternal vitamin use, and risk of high versus low level spina bifida defects.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR): incidence of mutations C677T and A1298C in Brazilian population and its correlation with plasma homocysteine levels in spina bifidaSemantic proximity Read ↗

Distribution of alleles of the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in familial spina bifida.Semantic proximity Read ↗

Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk.Semantic proximity Read ↗

Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis.Semantic proximity Read ↗

Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes.Semantic proximity Read ↗

[Frequency of C677T polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) in Chilean mothers of spina bifida cases and controls ].Semantic proximity Read ↗

Genetic studies of the cystathionine beta-synthase gene and myelomeningocele.Semantic proximity Read ↗

A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.Semantic proximity Read ↗

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