Article
Germline mutations in the vhl gene in patients presenting with phaeochromocytomas.
International journal of cancer - 29 Jul 1998
van der Harst E, de Krijger R R, Dinjens W N, Weeks L E, Bonjer H J, Bruining H A, Lamberts S W, Koper J W
Abstract excerpt
It has been shown that an appreciable percentage of patients presenting with primary, apparently sporadic phaeochromocytomas may in fact have von-Hippel-Lindau (VHL) disease. In order to investigate this, we retrospectively screened 68 patients, who had been operated on for phaeochromocytomas, fo...
Topics
- Adrenal Gland Neoplasms
- Adult
- Aged
- DNA
- Exons
- Female
- Genes, Tumor Suppressor
- Genetic Variation
- Humans
- Introns
- Leukocytes
- Ligases
- Male
- Middle Aged
- Mutation
- Pheochromocytoma
- Polymorphism, Single-Stranded Conformational
- Proteins