Article
Germline mutations in the vhl gene in patients presenting with phaeochromocytomas.
International journal of cancer - 29 Jul 1998
van der Harst E, de Krijger R R, Dinjens W N, Weeks L E, Bonjer H J, Bruining H A, Lamberts S W, Koper J W
Abstract excerpt
It has been shown that an appreciable percentage of patients presenting with primary, apparently sporadic phaeochromocytomas may in fact have von-Hippel-Lindau (VHL) disease. In order to investigate this, we retrospectively screened 68 patients, who had been operated on for phaeochromocytomas, for the presence of germline mutations in the vhl gene. DNA was isolated from peripheral-blood leukocytes and used to...
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